When it comes to weight loss medications, Ozempic® , Wegovy® and semaglutide are names that often pop up in discussions. They are all associated with impressive weight loss results, but what exactly sets them apart? In this comprehensive comparison, we’ll explore the nuances of semaglutide, Ozempic and Wegovy. Awareness of those differences will help you make an informed decision.


Multiple Medications, One Drug Class 

GLP-1 medications (glucagon-like peptide 1s) are one of the most effective drug classes on the market for long-term weight loss. GLP-1 medications simulate the natural hormone produced in the intestines that helps people feel full after they eat. It also stimulates insulin secretion. Doing so allows cells to take up glucose and inhibits glucagon secretion, which prevents more glucose from releasing into the bloodstream. All this lowers blood sugar levels. GLP-1s also increase satiety (how full you feel) after eating, which helps contribute to its weight loss properties (FDA.gov). There’s also evidence that they contribute to weight loss by lowering the body’s natural “set point” for weight.  

Semaglutide, Wegovy®, Ozempic®, and Rybelsus® are all semaglutide-based GLP-1 medications. Saxenda®, Victoza®, Trulicity®, Zepbound™ and Mounjaro® (Tirzepatide) are also GLP-1 medications with different active ingredients.  


Ozempic: The Trusted Name  

Ozempic, a once-weekly injectable medication manufactured by Novo Nordisk, is a well-known name in the pharmaceutical industry. It’s been FDA-approved to treat type 2 diabetes since 2017. A common misconception around Ozempic is that it’s prescribed for weight loss. Wegovy®, also manufactured by Novo Nordisk, is the higher-dose version of Ozempic® that is FDA-approved to treat obesity (FDA.gov). These medications are part of the GLP-1 class of medications. Semaglutide is the active ingredient found in both Ozempic® and Wegovy®.  


What Is Semaglutide?  

Semaglutide, a powerful GLP-1 receptor agonist, has been making waves in the world of weight loss and diabetes management (obesitymedicine.com). It’s the active ingredient used in FDA-approved medications Wegovy, Ozempic, and Rybelsus. Options Medical Weight Loss offers its patients a compounded semaglutide. Patients typically lose between 15-20% of their body weight. Options’ unique programs combine health coaching, Options Diet System and medical oversight from obesity-certified providers.  


Key Differences 

While all three medications contain semaglutide, the dosages do vary. Ozempic offers a maximum dose of 2.0 mg. Whereas Wegovy and Options’ semaglutide provides a dose that titrates up to 2.4 mg of semaglutide. The choice between the medications may depend on your specific needs, insurance coverage and preferences. 


Efficacy in Weight Loss  

Semaglutide and Ozempic/Wegovy have demonstrated significant efficacy in weight loss. Clinical trials have shown that they can lead to substantial reductions in body weight, making them a promising choice for individuals struggling with obesity.  


Lifestyle Transformation with Ozempic  

It’s important to note that achieving successful and sustainable weight loss with Ozempic, or any semaglutide-based medication, requires more than just taking the drug. Lifestyle changes are integral to the process. This may include dietary adjustments, exercise, adequate sleep, and emotional health management. Options’ health coaching guides patients through these adjustments. Options Medical Weight Loss Chief Medical Officer, Dr. Katrina Mattingly, developed the unique Options Diet System (ODS) to optimize fat loss and encourage muscle mass maintenance. Dr. Mattingly is board-certified in obesity medicine.  


Making the Right Choice 

Choosing between semaglutide and Ozempic/ Wegovy depends on various factors: 

  • weight loss goals 
  • physician’s recommendations 
  • insurance coverage 
  • personal preferences for oversight 

Discussing these options with your healthcare provider can help you make an informed decision.  

There are side effects to these medications, so discussing your personal risk factors with a medical provider is important. Common side effects are gastrointestinal disruptions such as nausea and vomiting.  



Semaglutide, Ozempic, and Wegovy are powerful players in the realm of weight loss medications. While semaglutide is the active ingredient they share, the dosing and branding differentiate them.  

Ultimately, your choice should align with your weight loss goals and the medical recommendation by your healthcare provider. These medications, when combined with lifestyle changes, can be instrumental in your weight loss journey. 

Options Medical Weight Loss offers patients with obesity access to safe, effective and affordable semaglutide medication within a comprehensive program 

Remember, always consult your healthcare professional before starting any weight loss medication to ensure it is safe and appropriate for your specific needs.